Connor Murray returns to partner Ian Keatley in the half backs while Rory Scannell is given his chance alongside star performer Francis Saili.
Dave Kicoyne is given the nod in the front row alongside fellow Ard Scoil man Mike Sherry and South African BJ Botha.
Tommy O’Donnell returns the Champions Cup at seven in a strong back row with captain CJ Stander and the resurgent Robin Copeland.
Munster: Andrew Conway; Keith Earls, Francis Saili, Rory Scannell, Simon Zebo; Ian Keatley, Conor Murray; Dave Kilcoyne, Mike Sherry, BJ Botha; Dave Foley, Mark Chisholm; Robin Copeland, Tommy O’Donnell, CJ Stander – capt.
Replacements: Niall Scannell, John Ryan, Mario Sagario, Billy Holland, Jack O’Donoghue, Tomás O’Leary, Denis Hurley, Ronan O’Mahony.